NFL Week 4 kicks off Thursday evening, because the Cardinals Payments host the Seahawks.
Listed below are the strains for each Week 4 matchup at DraftKings Sportsbook as of Sept. 21.
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(All instances ET)
2025 NFL Week 4 Odds
THURSDAY, SEPT. 25
SEAHAWKS @ CARDINALS
Unfold: Cardinals -1.5Moneyline: Cardinals -122, Seahawks +102Total O/U: 43.5
SUNDAY, SEPT. 28
VIKINGS @ STEELERS
Unfold: Vikings -1.5Moneyline: Vikings -125, Steelers +105Total O/U: 41.5
COMMANDERS @ FALCONS
Unfold: Commanders -3Moneyline: Commanders -155, Falcons +130Total O/U: 45.5
SAINTS @ BILLS
Unfold: Payments -15.5Moneyline: Payments -1600, Saints +900Total O/U: 48.5
BROWNS @ LIONS
Unfold: Lions -8.5Moneyline: Lions -380, Browns +300Total O/U: 45.5
PANTHERS @ PATRIOTS
Unfold: Patriots -4.5Moneyline: Patriots -205, Panthers +170Total O/U: 45.5
CHARGERS @ GIANTS
Unfold: Chargers -6Moneyline: Chargers -278, Giants +225Total O/U: 44.5
EAGLES @ BUCCANEERS
Unfold: Eagles -2.5Moneyline: Eagles -155, Bucs +130Total O/U: 45.5
TITANS @ TEXANS
Unfold: Texans -7Moneyline: Texans -355, Titans +280Total O/U: 40.5
COLTS @ RAMS
Unfold: Rams -4.5Moneyline: Rams -205, Colts +170Total O/U: 47.5
JAGUARS @ 49ERS
Unfold: 49ers -4.5Moneyline: 49ers -205, Jaguars +170Total O/U: 45.5
RAVENS @ CHIEFS
Unfold: Ravens -2.5Moneyline: Ravens -142, Chiefs +120Total O/U: 49.5
BEARS @ RAIDERS
Unfold: Bears -1.5Moneyline: Bears -115, Raiders -105Total O/U: 46.5
PACKERS @ COWBOYS
Unfold: Packers -5.5Moneyline: Packers -250, Cowboys +205Total O/U: 48.5
MONDAY, SEPT. 29
JETS @ DOLPHINS
Unfold: Dolphins -2.5Moneyline: Dolphins -148, Jets +124Total O/U: 45.5
BENGALS @ BRONCOS
Unfold: Broncos -7.5Moneyline: Broncos -375, Bengals +295Total O/U: 44.5
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