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2025 NFL Odds Week 1: Strains, Spreads for all 16 Video games

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September 2, 2025
Reading Time: 6 mins read
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2025 NFL Odds Week 1: Strains, Spreads for all 16 Video games


Alas, preseason is over. No extra gown rehearsals. The actual deal is right here.

It’s time to start out making some bets on actual video games.

The Tremendous Bowl champion Philadelphia Eagles will kick off the 2025 season by internet hosting their NFC East rivals, the Dallas Cowboys, on Sept. 4.

With a loaded Week 1 slate, let’s try the traces for every recreation at DraftKings Sportsbook as of Sept. 1. 

(All occasions ET)

2025 NFL Week 1 Odds

THURSDAY, SEPT. 4

COWBOYS @ EAGLES (8:20 p.m., NBC)

Level unfold: Eagles -8.5 (Eagles favored to win by 8.5 factors or extra, in any other case Cowboys cowl)Moneyline: Eagles -395 favorites to win (wager $10 to win $12.53 complete); Cowboys +310 underdogs to win (wager $10 to win $41 complete)Whole Over/Below: 47.5 factors scored by each groups mixed

FRIDAY, SEPT. 5

CHIEFS @ CHARGERS (8:15 p.m., YouTube)

Level unfold: Chiefs -3 (Chiefs favored to win by 3 factors or extra, in any other case Chargers cowl)Moneyline: Chiefs -170 favorites to win (wager $10 to win $15.88 complete); Chargers +142 underdogs to win (wager $10 to win $24.20 complete)Whole Over/Below: 45.5 factors scored by each groups mixed

SUNDAY, SEPT. 7

RAIDERS @ PATRIOTS (1 p.m., CBS)

Level unfold: Patriots -3 (Patriots favored to win by 3 factors or extra, in any other case Raiders cowl)Moneyline: Patriots -155 favorites to win (wager $10 to win $16.45 complete); Raiders +130 underdogs to win (wager $10 to win $23 complete)Whole Over/Below: 43.5 factors scored by each groups mixed

STEELERS @ JETS (1 p.m., CBS)

Level unfold: Steelers -3 (Steelers favored to win by 3 factors or extra, in any other case Jets cowl)Moneyline: Steelers -155 favorites to win (wager $10 to win $16.45 complete); Jets +130 underdogs to win (wager $10 to win $23 complete)Whole Over/Below: 38.5 factors scored by each groups mixed

DOLPHINS @ COLTS (1 p.m., CBS)

Level unfold: Colts -1.5 (Colts favored to win by 1.5 factors or extra, in any other case Dolphins cowl)Moneyline: Colts -112 favorites to win (wager $10 to win $18.93 complete); Dolphins -108 underdogs to win (wager $10 to win $19.26 complete)Whole Over/Below: 47.5 factors scored by each groups mixed

CARDINALS @ SAINTS (1 p.m., CBS)

Level unfold: Cardinals -6.5 (Cardinals favored to win by 6.5 factors or extra, in any other case Saints cowl)Moneyline: Cardinals -285 favorites to win (wager $10 to win $13.51 complete); Saints +230 underdogs to win (wager $10 to win $33 complete)Whole Over/Below: 43.5 factors scored by each groups mixed

GIANTS @ COMMANDERS (1 p.m., FOX and FOX Sports activities app)

Level unfold: Commanders -6 (Commanders favored to win by 6 factors or extra, in any other case Giants cowl)Moneyline: Commanders -265 favorites to win (wager $10 to win $13.77 complete); Giants +215 underdogs to win (wager $10 to win $31.50 complete)Whole Over/Below: 45.5 factors scored by each groups mixed

PANTHERS @ JAGUARS (1 p.m., FOX and FOX Sports activities app)

Level unfold: Jaguars -3.5 (Jaguars favored to win by 3.5 factors or extra, in any other case Panthers cowl)Moneyline: Jaguars -180 favorites to win (wager $10 to win $15.56 complete); Panthers +150 underdogs to win (wager $10 to win $25 complete)Whole Over/Below: 46.5 factors scored by each groups mixed

BENGALS @ BROWNS (1 p.m., FOX and FOX Sports activities app)

Level unfold: Bengals -5.5 (Bengals favored to win by 5.5 factors or extra, in any other case Browns cowl)Moneyline: Bengals -238 favorites to win (wager $10 to win $14.20 complete); Browns +195 underdogs to win (wager $10 to win $29.50 complete)Whole Over/Below: 47.5 factors scored by each groups mixed

BUCCANEERS @ FALCONS (1 p.m., FOX and FOX Sports activities app)

Level unfold: Buccaneers -2.5 (Buccaneers favored to win by 2.5 factors or extra, in any other case Falcons cowl)Moneyline: Buccaneers -135 favorites to win (wager $10 to win $17.41 complete); Falcons +114 underdogs to win (wager $10 to win $21.40 complete)Whole Over/Below: 47.5 factors scored by each groups mixed

TITANS @ BRONCOS (4:05 p.m., FOX and FOX Sports activities app)

Level unfold: Broncos -7.5 (Broncos favored to win by 7.5 factors or extra, in any other case Titans cowl)Moneyline: Broncos -380 favorites to win (wager $10 to win $12.63 complete); Titans +300 underdogs to win (wager $10 to win $40 complete)Whole Over/Below: 42.5 factors scored by each groups mixed

49ERS @ SEAHAWKS (4:05 p.m., FOX and FOX Sports activities app)

Level unfold: 49ers -2.5 (49ers favored to win by 2.5 factors or extra, in any other case Seahawks cowl)Moneyline: 49ers -135 favorites to win (wager $10 to win $17.41 complete); Seahawks +114 underdogs to win (wager $10 to win $21.40 complete)Whole Over/Below: 43.5 factors scored by each groups mixed

LIONS @ PACKERS (4:25 p.m., CBS)

Level unfold: Packers -2.5 (Packers favored to win by 2.5 factors or extra, in any other case Lions cowl)Moneyline: Packers -148 favorites to win (wager $10 to win $16.76 complete); Lions +124 underdogs to win (wager $10 to win $22.40 complete)Whole Over/Below: 46.5 factors scored by each groups mixed

TEXANS @ RAMS (4:25 p.m., CBS)

Level unfold: Rams -3 (Rams favored to win by 3 factors or extra, in any other case Texans cowl)Moneyline: Rams -155 favorites to win (wager $10 to win $16.45 complete); Texans +130 underdogs to win (wager $10 to win $23 complete)Whole Over/Below: 43.5 factors scored by each groups mixed

RAVENS @ BILLS (8:20 p.m., NBC)

Level unfold: Payments -1.5 (Payments favored to win by 1.5 factors or extra, in any other case Ravens cowl)Moneyline: Payments -112 favorites to win (wager $10 to win $18.93 complete); Ravens -108 underdogs to win (wager $10 to win $19.26 complete)Whole Over/Below: 50.5 factors scored by each groups mixed 

MONDAY, SEPT. 8

VIKINGS @ BEARS (8:15 p.m., ESPN)

Level unfold: Vikings -1.5 (Vikings favored to win by 1.5 factors or extra, in any other case Bears cowl)Moneyline: Vikings -125 favorites to win (wager $10 to win $18 complete); Bears +105 underdogs to win (wager $10 to win $20.50 complete)Whole Over/Below: 44.5 factors scored by each groups mixed

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