NFL Week 5 kicks off Thursday evening, because the Rams host the 49ers.
Listed here are the strains for each Week 5 matchup at DraftKings Sportsbook as of Sept. 29.
(All occasions ET)
2025 NFL Week 5 Odds
THURSDAY, OCT. 2
49ERS @ RAMS
Unfold: Rams -3Moneyline: Rams -180, 49ers +150Total O/U: 47.5
SUNDAY, OCT. 5
VIKINGS @ BROWNS
Unfold: Vikings -4.5Moneyline: Vikings -218, Browns +180Total O/U: 37.5
BRONCOS @ EAGLES
Unfold: Eagles -5.5Moneyline: Eagles -238, Broncos +195Total O/U: 43.5
TEXANS @ RAVENS
Unfold: TBDMoneyline: TBDTotal O/U: TBD
RAIDERS @ COLTS
Unfold: Colts -6.5Moneyline: Colts -298, Raiders +240Total O/U: 48.5
COWBOYS @ JETS
Unfold: Cowboys -1.5Moneyline: Cowboys -125, Jets +105Total O/U: 46.5
DOLPHINS @ PANTHERS
Unfold: Dolphins -1.5Moneyline: Dolphins -125, Panthers +105Total O/U: 46.5
GIANTS @ SAINTS
Unfold: Giants -2.5Moneyline: Giants -135, Saints +114Total O/U: 42.5
BUCCANEERS @ SEAHAWKS
Unfold: Seahawks -2.5Moneyline: Seahawks -142, Buccaneers +120Total O/U: 45.5
TITANS @ CARDINALS
Unfold: Cardinals -8.5Moneyline: Cardinals -500, +380Total O/U: 41.5
LIONS @ BENGALS
Unfold: Lions -8.5Moneyline: Lions -440, Bengals +340Total O/U: 48.5
COMMANDERS @ CHARGERS
Unfold: Chargers -3Moneyline: Chargers -166, Commanders +140Total O/U: 47.5
PATRIOTS @ BILLS
Unfold: Payments -8.5Moneyline: Payments -470, Patriots +360Total O/U: 50.5
MONDAY, OCT. 6
CHIEFS @ JAGUARS
Unfold: Chiefs -3Moneyline: Chiefs -166, Jaguars +140Total O/U: 45.5
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