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5 Dietary supplements and Drugs To not Combine With Fish Oil

greater by greater
November 17, 2025
Reading Time: 4 mins read
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5 Dietary supplements and Drugs To not Combine With Fish Oil



One in 5 adults over age 60 takes fish oil, a complement extracted from the tissues of fatty fish and wealthy in omega-3 fatty acids, which help coronary heart, mind, eye, and joint well being. However despite the fact that omega-3s have advantages, sure medicines and dietary supplements can work together with fish oil in probably dangerous methods. Listed here are 5 of them.

Omega-3 dietary supplements can inhibit blood-clotting, which often isn’t a problem once they’re taken on their very own, Aaron Emmel, PharmD, a pharmacist and the founder and director of instructional applications at Pharmacy Tech Scholar, informed Well being.

Nonetheless, mixing omega-3s with medicines which have related results, resembling anticoagulants like warfarin or antiplatelet medicine like aspirin, may improve the chance of bleeding, he stated. 

For those who take these medicines, discuss to your doctor earlier than including fish oil. They could wish to monitor your worldwide normalized ratio, which measures how lengthy it takes in your blood to clot, famous Amy Goldsmith, RDN, LDN, a registered dietitian and proprietor of Kindred Diet & Kinetics in Frederick, Maryland.

Ginkgo biloba, an natural complement typically taken for mind well being and situations like nervousness or PMS, additionally has antiplatelet properties that make it tougher for blood to clot, stated Brynna Connor, MD, ABFM, a board-certified household drugs doctor and healthcare ambassador at NorthWestPharmacy.com.

That’s why combining it with fish oil will increase the chance of bruising or bleeding, she informed Well being.

Vitamin E—an antioxidant linked to immune, coronary heart, and eye well being—additionally thins the blood. When taken alongside fish oil, it could possibly additional elevate the chance of bleeding or bruising.

Most adults can meet the beneficial 15 milligrams (mg) per day of vitamin E by meals like vegetable oils, nuts, seeds, spinach, and broccoli. Dietary supplements typically present greater than you want, which can worsen the chance when mixed with fish oil.

NSAIDs resembling ibuprofen and naproxen scale back ache and irritation however can improve the chance of inside bleeding, particularly within the gastrointestinal tract. As a result of omega-3s have anticoagulant properties, taking each on the identical time may be dangerous.

“NSAIDs have an elevated bleeding danger with excessive fish-oil doses,” Goldsmith stated, so the pairing ought to be supervised by your supplier.

Omega-3s can barely lower blood strain. When mixed with blood pressure-lowering medicines like ACE inhibitors, beta blockers, and calcium channel blockers, the consequences could trigger blood strain to drop too low, Emmel stated.

“This doesn’t imply that you simply completely can’t take fish oil with these dietary supplements,” he famous. “Nonetheless, if you happen to take them collectively, achieve this with warning.”

Any hostile results from fish oil often occur with larger doses—greater than 3,000 mg of mixed EPA and DHA per day. “Usually, the usual OTC dose is 1,000 to 2,000 mg of complete fish oil each day, and it ought to be secure so long as it’s monitored and guided by your physician,” Emmel stated.

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That stated, many individuals could not have to take fish oil in any respect. All three consultants beneficial getting omega-3s out of your weight-reduction plan earlier than turning to dietary supplements. You may possible meet the beneficial consumption by consuming two to a few servings of fish per week (a 3-ounce serving of salmon, for instance, has about 2,000 mg of DHA and EPA).

“Dietary supplements are greatest for these people who don’t eat fish, or those that want therapeutic supplementation for situations like excessive triglycerides, heart problems danger, and rheumatoid arthritis,” Connor informed Well being. 

For individuals who do want dietary supplements, Connor recommended selecting ones in triglyceride or re-esterified triglyceride type, that are extra bioavailable than the ethyl ester type. Take them with a meal that features some dietary fats to boost absorption, she stated.

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