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Home Health

Widespread Tongue Circumstances in Individuals With HIV

greater by greater
July 13, 2025
Reading Time: 7 mins read
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Widespread Tongue Circumstances in Individuals With HIV



Mouth and tongue lesions are sometimes one of many first signs of human immunodeficiency virus (HIV). HIV weakens your immune system, which may depart you vulnerable to sores and infections.

If left untreated, oral well being points could cause ache and different well being problems.

frank600 / Getty Photos


Aphthous ulcers are small, yellow or grey sores with a purple border. They normally seem on the tongue, cheeks, or contained in the lips. Mouth ulcers could make speaking and consuming painful, particularly in the event that they’re situated below the tongue.

Mouth ulcers are sometimes a symptom of a weak immune system and stress. An estimated 50% of individuals with HIV expertise mouth and tongue ulcers due to their weakened immune techniques. Dry mouth brought on by HIV and HIV drugs can even improve your danger of mouth sores.

Sores will ultimately heal on their very own. Delicate ulcers could be handled with over-the-counter (OTC) numbing lotions that assist relieve ache and promote therapeutic. Extra extreme sores are handled with prescription corticosteroid mouthwashes or tablets.

Tunatura / Getty Photos


Oral thrush is a kind of yeast an infection that causes patches of creamy white or yellow bumps that coat the tongue. These patches could be painless, or they could burn and bleed. Oral thrush can even have an effect on the tonsils, throat, cheeks, gums, and roof of the mouth. 

Oral thrush is the commonest mouth an infection that impacts individuals dwelling with HIV. It is regular for yeast (a kind of fungus) to dwell in your mouth. Nevertheless, if in case you have a weakened immune system as a result of HIV, it is simpler for this fungus to develop an excessive amount of, resulting in an infection. As a result of saliva within the mouth has antibodies to struggle infections, HIV-related dry mouth additionally will increase your danger of oral thrush.

Prescription antifungal lozenges, tablets, or mouthwashes can deal with oral thrush. Nevertheless, oral thrush typically returns in case your immune system is simply too weak.

Oral furry leukoplakia (OHL).
Photograph Credit score: U.S. Facilities for Illness Management and Prevention

Oral furry leukoplakia (OHL) causes white, hair-like patches on the perimeters of the tongue. It may well additionally seem on the insides of the cheeks and decrease lip. These patches could be painless or trigger delicate ache. In additional extreme circumstances, you might lose your sense of style and expertise cold and hot sensitivity.

Individuals with Epstein-Barr virus (EBV)—a standard herpes virus—can develop oral furry leukoplakia. EBV usually infects individuals with extraordinarily weak immune techniques, particularly these with HIV. EBV infections are additionally extra frequent in individuals with untreated HIV.

Oral furry leukoplakia patches typically go away randomly, however there isn’t any remedy for the underlying Epstein-Barr virus. Remedy for OHL might embody prescription anti-retroviral drugs to assist scale back patches and decrease EBV in your physique. Topical options, like podophyllin resin and retinoids, will also be utilized to the tongue to take away patches. 

ardasavasciogullari / Getty Photos


Herpes simplex virus sort 1 (HSV-1) could cause swollen, painful sores and blisters on the tongue. Blisters are additionally frequent on the lips and the roof of the mouth. Herpes blisters begin as small clusters of white or yellow fluid-filled bumps that ultimately burst into one bigger purple sore. 

Oral herpes impacts almost 20% of individuals with HIV. Residing with a weak immune system will increase your danger of getting extra oral herpes outbreaks, which may additionally unfold extra simply.

Herpes sores are very contagious and might unfold from kissing or sharing utensils. There is no such thing as a remedy for oral herpes, however prescription antivirals may also help scale back therapeutic time and future outbreaks.

Sol Silverman, Jr., DDS / CDC


Oral warts appear to be small, onerous, skin-colored bumps or flat, white growths that resemble cauliflower. These painless warts typically seem on the tongue, lips, and inside the mouth. On the tongue, warts normally look grey or white and develop on the perimeters of the tongue or the lingual frenulum (the fold beneath your tongue).

Oral warts are brought on by completely different strains of the human papillomavirus (HPV). Individuals with HIV usually tend to get HPV infections and oral warts due to their weakened immune system.

People who find themselves getting older with HIV or are doing extremely energetic antiretroviral remedy (HAART) are additionally at an elevated danger of oral warts. Oral warts could be eliminated surgically or frozen off with cryosurgery. Nevertheless, warts can come again. 

MSC / Getty Photos


Oral melanin hyperpigmentation appears to be like like flat, brown patches on the tongue, lips, gums, cheeks, or roof of the mouth. This discoloration is brought on by elevated melanin (pores and skin pigment) within the mouth.

When you’ve got HIV, the antiretroviral remedy (ART) medicine Retrovir (zidovudine), also referred to as AZT, could cause oral hyperpigmentation as a facet impact. HIV-related oral hyperpigmentation would not normally trigger issues or require therapy. Nevertheless, for those who’re apprehensive concerning the look of hyperpigmentation, discuss together with your healthcare supplier. You could possibly swap to a special ART medicine.

Sustaining good oral hygiene may also help stop HIV tongue and mouth circumstances. Some dentist-approved suggestions embody:

Preserve your mouth clear: Brush your tooth for 2 minutes and floss twice day by day to take away meals, plaque, and dangerous micro organism in your mouth. 
Go to your dentist usually: See your dentist at the very least each six months for cleanings. If you do not have a dentist, ask your healthcare supplier or clinic for a referral. 
Take your HIV medicine: It is vital to take antiretroviral remedy drugs as directed and on schedule to scale back HIV in your physique and assist your immune system get better.
Keep away from dry mouth triggers: Restrict issues that may result in dry mouth, like smoking tobacco, consuming alcohol, and consuming salty meals.
Keep hydrated: Drink water typically, use a humidifier at bedtime, and think about using toothpaste or mouthwash designed to assist dry mouth.

When you’ve got HIV, it is vital to see your supplier for those who expertise any modifications in your mouth or tongue. Mouth sores, dry mouth, and oral infections are sometimes indicators that HIV is progressing and the immune system is turning into weaker. Some HIV drugs can even make dry mouth worse, so your supplier might advocate a special therapy.

If left untreated, oral well being problems make you extra vulnerable to bacterial infections and septicemia (blood poisoning), which could be deadly with a weakened immune system. HIV-related tongue ulcers and dry mouth could cause ache that makes it onerous to speak, chew, and swallow. Tongue lesions can even put on down style buds and trigger lack of style.

Different warning indicators of HIV development that warrant a medical go to embody:

FatigueFeverChillsSore throatMouth ulcersRashMuscle achesSwollen lymph nodesNight sweats

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